Madonna, Genesis, Foo Fighters and the Red Hot Chili Peppers are to play at the new Wembley Stadium for a concert highlighting the threat of climate change.
Other acts at the London leg of the Live Earth series of concerts include James Blunt, Duran Duran, Snow Patrol, Razorlight and Damien Rice.
Seven Live Earth shows will take place around the world on July 7.
The initiative aims to bring together more than 2 billion people to combat the climate crisis with performances from 100 headliners.
It involves, Stop Climate Chaos, a coalition of campaign groups including many faith groups.
Live Earth’s 24 hours of music across 7 continents will deliver a call to action to combat the climate crisis. It will mark the beginning of a multi-year mass persuasion campaign led by The Alliance for Climate Protection to move individuals, corporations and governments to solve the climate crisis.
The line-up for the UK leg of the 24 hour event was announced yesterday by Live Earth founder and executive producer Kevin Wall.
"This monster line-up will ensure Live Earth meets our goal of bringing together people from around the world to combat the climate crisis. Live Earth will not only span all seven continents, but the musicians who have answered our call span multiple genres and generations" he said.
Other concerts will take place in New York, Sydney, Tokyo, Rio de Janeiro's Copacabana Beach, Johannesburg's Cradle of Human Kind, and on the steps of the Oriental Pearl Tower in Shanghai.
The Police, Kanye West and Bon Jovi will headline the US leg at Giants Stadium in New Jersey. More acts will be announced for all venues later in the year.
So far the eclectic London line-up also includes American hip-hop groups the Black Eyed Peas and the Beastie Boys, indie band Bloc Party, singer-songwriter David Gray and R&B pianist John Legend.
Other artists on the bill for Wembley are Corinne Bailey Rae, Keane and Paolo Nutini. Tickets for the London concert, £55 each, will be allocated by public ballot.
Proceeds from the concerts will fund a new global effort to combat climate change led by the Alliance for Climate Protection, whose chairman is former US vice-president Al Gore.
"By attracting an audience of billions, we hope Live Earth will launch a global campaign giving a critical mass of people around the world the tools they need to help solve the climate crisis," Mr Gore said. "But ultimately, corporations and governments must become global leaders taking decisive action to stop global warming."
Ashok Sinha, director of Stop Climate Chaos, said: "What we will be able to do is engage with people who have been energised by the concerts afterwards and talk to them about what action they can take themselves. If this was just going to be a concert and nothing else we wouldn't be supporting it."