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His trip to Cuba will be the pontiff's second visit to Latin America, home to almost half of the world's Catholics. Benedict XVI visited Brazil in 2007.
Church leaders from the US and Cuba have wrapped up a five-day meeting in Havana with a call for "normalised relations" between the two countries.
As Cuba moves toward a post-Fidel Castro society, its churches are finding ways to "give a Christian witness with integrity" in a state-controlled country.